Skip to site alert. Skip to content. Here he received training in addiction psychiatry research under the mentorship of Drs.
Marian Fischman and Herbert Kleber. Bisaga became a faculty at the Department of Psychiatry in and he was promoted to the rank of Professor in His research interests include development of human laboratory and clinical trial models and testing medications to treat opioid, cocaine, and tobacco use disorders.
Besides his research contributions Dr. He has been working with UN Office of Drug Control on the development of substance abuse treatment guidelines and conducted trainings for addiction practitioners internationally. In addition to the research and teaching work at the University, Dr. Bisaga also maintains a private practice in addiction psychiatry. The Division of Substance Abuse has a very active program to develop medications for this condition.
Small N clinical trials can offer initial data on the efficacy and the mechanism of action of promising medications. Bisaga and his colleagues are interested in improving the design of clinical trials to test specific, laboratory-derived hypotheses about the potential spectrum of medication efficacy and to screen for new medication.
This research group is particularly interested in the effectiveness of medication that acts on inhibitory and excitatory neurotransmission to modulate effects of cocaine. Opioid dependence treatment trials: improving effectiveness of naltrexone maintenance The number of new prescription opioids and heroin users and associated has increased steadily over the past several years.
While methadone maintenance remains the most effective treatment for opioid dependence, it has several limitations and is controversial.
Naltrexone maintenance is an alternate treatment for opiate dependence that is promising, but currently has limited usefulness due to poor patient compliance and low patient acceptability. Bisaga and his colleagues are interested whether adding additional medications, such as glutamatergic antagonists will improve the effectiveness of naltrexone to prevent relapse in detoxified heroin-dependent individuals. Development of human laboratory models of addictive disorders and testing novel compounds using these models Laboratory models of addictive disorders can offer unique opportunity to study mechanisms of disease and to screen for potential pharmacotherapies.
Medications that block subjective effects, withdrawal symptoms, drug craving, or drug self-administration in the non-treatment-seeking volunteers who participate in the laboratory study may be effective in the treatment of addictive disorders.
Currently Dr. Bisaga and colleagues are developing laboratory models of alcohol and nicotine dependence.Scott torbica za bicikl. Prati Dodato u Pratim. Facebook Twitter Kopiraj link. Torbica za ram. Torbica za ram sa folijom za telefon osetljivom na dodir, Topeak Beam Rack torba. Topeak Beam Rack torba Topeak torba I paktreger na Adapter se montira na ram, ispod Plasticna korpaAluminijumska din. Torbica za bicikl. Kao sa slika Druga din Imate opciju goredesno Uz biciklu iz mojih Navlaka, zastita kabanica za duple bisage, torbu za bicikl 5.
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Bisaga Jeff PhD
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If you see comments in violation of our community guidelinesplease report them. And now, other similar but even stronger synthetics are seeping into heroin streams. It's another fentanyl analog, made overseas, More worrisome, it isn't even listed as a controlled substance in the United States. Any of the drugs could be the culprit of the mass of overdoses that totaled nearly in Cincinnati from Aug. Three people died. The number of overdoses is far higher than the four-per-day that Cincinnati had previously experienced.
The surges are also tormenting Northern KentuckyLouisville and other communities and states. The Hamilton County coroner, Dr. Lakshmi Sammarco, is awaiting toxicology reports on the blood of three people who overdosed during the first week that Cincinnati experienced the barrage. Heroin, he noted, requires not only planting poppies but having guards for the crop, making the drug and smuggling into the United States. The U. Drug Enforcement Administration says the synthetic drugs are made in labs overseas, primarily in China, and shipped to Mexico or Canada, where Mexican drug organizations intercept them.
The Canadian Border Services has found both fentanyl and carfentanil in packages. Some Canadian researchers are already saying their heroin supplies appear to be down, replaced with fentanyl. And while there's still heroin around, harm reduction health workers are noting a surge in fentanyl that is worrisome.
Still, Virani said he wouldn't be surprised if heroin fades off. And he hopes people fighting addiction stay focused on the bigger picture of the synthetics:. It feels much like a game of whack-a-mole, except each novel chemical that comes into the illicit market" is stronger and deadlier. That's because nobody tests for the synthetics in people, until an overdose occurs.
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Could powerful 'fakes' be the new heroin? Post to Facebook.Ron Bisaga is 50 years old. Online, Ron goes by the aliases bisagaii and stinger Fresno, CA. Polly Bisaga lives in Fresno, California. On the internet, Polly goes by the alias pollybisaga. Leesburg, VA. Gary J Bisaga is 60 years old. He lives in Leesburg, VA. Marlton, NJ. Wildwood, MO.
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Bisaga Jeff PhD 5. Update Profile. Report Incorrect Info. Primary Specialty Psychologist. A psychologist focuses on the evaluation, prevention, diagnosis, and treatment of mental, emotional and behavioral health issues. A clinical psychologist uses psychotherapy and other counseling skills to improve emotional and mental health. Consumer Feedback. View All 2 Reviews Add a Review. Recent Reviews 5.
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AIMS: We hypothesized that memantine, a low-potency, uncompetitive NMDA receptor antagonist, would be safe and effective when used as an adjunct to oral naltrexone in the treatment of opioid dependence, particularly in preventing relapse to opiate use in detoxified individuals.
The primary outcome was the retention in treatment since treatment dropout is most commonly associated with relapse to opiate use. Twenty-six percent of participants withdrew from treatment prior to starting naltrexone. There was no significant difference in treatment retention or heroin use, opiate withdrawal symptoms and craving between the groups treated with memantine versus placebo.
Opiate use, particularly use of prescription analgesics, remains a serious public health problem affecting a growing number of individuals in the US SAMHSA, While agonist maintenance with methadone or buprenorphine remains the treatment of choice for individuals with a chronic and relapsing course of opioid dependence Mattick et al.
Further, agonist maintenance is not available or acceptable to many patients, nor is it universally effective. Naltrexone, a mu-opioid antagonist, acts by a different mechanism and offers an alternative approach to treatment Johansson et al.
Naltrexone blocks the effects of opioids, while producing no agonist effects itself, and thus may be helpful to patients who are not suitable for agonist maintenance or have failed prior trials of agonist treatment. Naltrexone initiation is preferably implemented directly following detoxification and as such it often coincides with the symptomatic treatment of the residual opiate withdrawal with hypnotics, anxiolytics, and non-opiate analgesics.
However, the effectiveness of this approach has been limited as a significant proportion of patients continue to report physical discomfort and, attributing these withdrawal symptoms to naltrexone, make the decision to discontinue naltrexone during the initiation phase and relapse to opioid use. One of the approaches to improve the tolerability of naltrexone induction would involve targeting pathways that mediate residual opiate withdrawal and those responsible for relapse during stabilization on naltrexone.
Glutamatergic neurotransmission, an important component of the endogenous reward system, is a viable target. Glutamate receptor antagonists attenuate drug-conditioned response, reduce the development and expression of physical dependence, and attenuate the reinforcing effects of opioids in preclinical models Bisaga and Popik, ; Gass and Olive, As an uncompetitive NMDA receptor antagonist, memantine blocks transmission when this receptor is in the active open state, such as in conditions of excess glutamate concentration Parsons et al.
Memantine is well tolerated in humans, with mild positive subjective effects and possible thymoleptic and anxiolytic effects Skolnick and Krystal, Memantine has produced encouraging results in animal laboratory models of opioid dependence, where it decreased aversive and physical signs of morphine withdrawal Harris et al. In human laboratory studies memantine, given in a single dose of 60 mg, attenuated the severity of opioid withdrawal Bisaga et al.
We hypothesized that decreasing glutamatergic neurotransmission using memantine could be effective in modulating glutamate-dependent mechanisms that contribute to relapse and discontinuation of treatment by individuals receiving naltrexone. To test this, we conducted a placebo-controlled trial of memantine in detoxified opioid dependent individuals that started receiving naltrexone and were being discharged to outpatient care.
We hypothesized that memantine would reduce protracted symptoms of opiate withdrawal and heroin craving, resulting in a decrease of opioid use and prevention of relapse in detoxified individuals treated with oral naltrexone. Medical assessment included history, laboratory tests, electrocardiogram ECGa physical examination, and a psychiatric evaluation. Included were men and women 18—60 years old, who met DSM-IV criteria for current opioid dependence and used opioids daily.
Individuals with major affective or psychotic disorder were excluded. Other exclusion criteria included: 1 regular use of methadone; 2 history of accidental opioid overdose, 3 ongoing treatment with prescription opioids or psychotropic agents; 4 physiological dependence on alcohol or sedative-hypnotics, 5 unstable physical disorders which might make participation hazardous. Following study consent, participants were admitted to an inpatient unit at the New York State Psychiatric Institute for the purpose of detoxification and naltrexone induction.
We have used a modification of a buprenorphine-assisted, rapid opioid detoxification and naltrexone induction procedure Collins et al. Briefly, participants were stabilized on buprenorphine for 1 day, followed by a washout period of 1—2 days, then given an increasing daily dose of naltrexone Participants were discharged with small supplies and week-long tapering schedules for adjuvant medications that they have been receiving in the hospital clonidine, trazodone, and zolpidem.
Following discharge, participants continued treatment with memantine or placebo for 12 weeks. Both participants and study personnel were blind to medication assignment.
Memantine tablets were encapsulated with 25 mg of riboflavin, added by the research pharmacy of the New York State Psychiatric Institute, as a urine marker to assess compliance. A matching capsule containing folic acid tablets and riboflavin was used as a placebo. Throughout the 12 weeks of the study, participants received 3 medication capsules daily 1 in the morning and 2 in the eveningeach containing memantine 10 mg, memantine 20mg, or placebo, each encapsulated with 25 mg of riboflavin.
This dose has been safely administered in human laboratory studies Bisaga et al. All participants received naltrexone during the week study.Software Engineer with a demonstrated history of working in the tech industry. Skilled in object-oriented programming, problem solving, and design thinking.
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